UniProt ID: F1QYJ6 |
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including dopamine, T3 (triiodo-L-thyronine), T4 (thyroxine), flavonoids, isoflavonoids, and other phenolic compounds. {ECO:0000269|PubMed:12507510}. CATALYTIC ACTIVITY: Reaction=3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'- bisphosphate + H(+) + thyroxine sulfate; Xref=Rhea:RHEA:26422, ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343, ChEBI:CHEBI:58910, ChEBI:CHEBI:305790; EC=2.8.2.n2; ACTIVITY REGULATION: Strongly inhibited by the divalent metal cations Fe(2+), Hg(2+), Co(2+), Zn(2+), Cu(2+) and Cd(2+). {ECO:0000269|PubMed:12507510}. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7-9. {ECO:0000269|PubMed:12507510}; Temperature dependence: Thermostable between 20-43 degrees Celsius. {ECO:0000269|PubMed:12507510}; SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P0CC03}. SIMILARITY: Belongs to the sulfotransferase 1 family. {ECO:0000255|RuleBase:RU361155}. SEQUENCE CAUTION: Sequence=AAH93112.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. Contains sequence from chromosome 22 in the C-terminus.; Evidence={ECO:0000305}; |
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