UniProt ID: Q566V3
FUNCTION: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O- methylguanosine at position 1485 (Gm1485) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. {ECO:0000250|UniProtKB:Q9HC36, ECO:0000305|PubMed:25009282}.
CATALYTIC ACTIVITY: Reaction=a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O- methyluridine in rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54152, Rhea:RHEA-COMP:13812, Rhea:RHEA- COMP:13814, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; Evidence={ECO:0000250|UniProtKB:Q9HC36};
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9HC36}.
SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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