UniProt ID: F1QIC2
SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000256|SAAS:SAAS00583414}.
UniProt ID: Q58EN8
FUNCTION: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating vipas39. In epithelial cells, the vps33b:vipas39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (By similarity). Plays a role in bile duct development. {ECO:0000250|UniProtKB:P59016, ECO:0000250|UniProtKB:Q9H267, ECO:0000269|PubMed:16284120, ECO:0000269|PubMed:20190753}.
SUBUNIT: Interacts with vipas39. {ECO:0000250|UniProtKB:P59016, ECO:0000250|UniProtKB:Q9H267}.
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q9H267}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H267}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H267}. Lysosome membrane {ECO:0000250|UniProtKB:Q9H267}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H267}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H267}. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q9H267}.
TISSUE SPECIFICITY: Widely expressed from 4 hours post- fertilization (hpf) to 24 hpf. At 48 hpf, localized to brain, retina, ear, liver and proximal intestine. This expression pattern is more pronounced at 72 hpf and persists through 5 days post- fertilization (dpf). At 3 dpf and 4 dpf, expression in the liver is predominantly in developing biliary epithelial cells. No expression detected in kidney or spinal cord. {ECO:0000269|PubMed:16284120, ECO:0000269|PubMed:20190753}.
SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family. {ECO:0000255}.
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