UniProt ID: Q58EG2
FUNCTION: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex. {ECO:0000250|UniProtKB:O75477}.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O94905, ECO:0000255}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O94905, ECO:0000255}. Note=Associated with lipid raft-like domains of the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:O94905, ECO:0000255}.
SIMILARITY: Belongs to the band 7/mec-2 family. {ECO:0000255}.
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