UniProt ID: B0V3F8
FUNCTION: Activates eif2ak2/pkr in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of eif2s1/efi2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by dicer1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by dicer1 (By similarity). {ECO:0000250}.
SUBUNIT: Homodimer. Interacts with dicer1 and eif2ak2/pkr. Also able to interact with dsRNA (By similarity). {ECO:0000250}.
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
SIMILARITY: Belongs to the PRKRA family. {ECO:0000305}.
SEQUENCE CAUTION: Sequence=CAQ15450.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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