UniProt ID: F1QH25 |
SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}. |
UniProt ID: Q58G59 |
FUNCTION: Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. {ECO:0000269|PubMed:15647323, ECO:0000269|PubMed:24339784}. SUBUNIT: Binds microtubules. Interacts with gli1 and sufu. {ECO:0000269|PubMed:15647323, ECO:0000269|PubMed:24339784}. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15647323}. Cell projection, cilium {ECO:0000250}. SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily. {ECO:0000255|PROSITE- ProRule:PRU00283}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |