UniProt ID: Q5D013 |
FUNCTION: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. {ECO:0000255|HAMAP- Rule:MF_03188}. CATALYTIC ACTIVITY: Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA- COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; Evidence={ECO:0000250|UniProtKB:Q5JPI9}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193; Evidence={ECO:0000250|UniProtKB:Q5JPI9}; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03188}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03188}. SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. {ECO:0000255|HAMAP-Rule:MF_03188}. |
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