UniProt ID: Q29RB4 |
FUNCTION: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Secreted {ECO:0000250}. SIMILARITY: Belongs to the OLFML3 family. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAI14288.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
This information was provided by UniProt through a collaboration with ZFIN. (1) |