FUNCTION: Lysine demethylase that demethylates both histones and non- histone proteins. Mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2). Recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity). {ECO:0000250|UniProtKB:O75151}. SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:O75151}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:O75151}. SIMILARITY: Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAH60927.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; |