UniProt ID: Q5EAP5 |
FUNCTION: Transcription factor that acts as a key regulator of ciliogenesis (PubMed:22233545). Specifically regulates expression of genes required for cilium assembly and function (PubMed:22233545). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (By similarity). {ECO:0000250|UniProtKB:P48379, ECO:0000269|PubMed:22233545}. SUBUNIT: Homodimer. Heterodimer; heterodimerizes with other rfx proteins. {ECO:0000250|UniProtKB:P48379}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B2GV50, ECO:0000255|PROSITE-ProRule:PRU00858}. Cytoplasm {ECO:0000250|UniProtKB:B2GV50}. Note=Mainly expressed in the nucleus and at lower level in cytoplasm. {ECO:0000250|UniProtKB:B2GV50}. DISRUPTION PHENOTYPE: Reduced cilia length in the Kupffer's vesicle and impaired left-right asymmetry. {ECO:0000269|PubMed:22233545}. SIMILARITY: Belongs to the RFX family. {ECO:0000255|PROSITE- ProRule:PRU00858}. |
UniProt ID: A0A8M2BEA3 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. |
UniProt ID: A0A8M2BEC2 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |