UniProt ID: F1R983 |
FUNCTION: Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. {ECO:0000250|UniProtKB:Q99708}. SUBUNIT: Homodimer; dimerizes via the coiled coil domain. Interacts with the MRN complex; the interaction links DNA sensing to resection (By similarity). Interacts with samhd1 (By similarity). {ECO:0000250|UniProtKB:Q6GNV6, ECO:0000250|UniProtKB:Q99708}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99708}. Note=Associates with sites of DNA damage in S/G2 phase. {ECO:0000250|UniProtKB:Q99708}. SIMILARITY: Belongs to the COM1/SAE2/CtIP family. {ECO:0000305}. |
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