UniProt ID: A1L2G3 |
FUNCTION: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). {ECO:0000250|UniProtKB:Q92560}. CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000250|UniProtKB:Q92560}; SUBUNIT: Component of the PR-DUB complex. {ECO:0000250|UniProtKB:Q92560}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q92560}. Nucleus {ECO:0000250|UniProtKB:Q92560}. Note=Mainly nuclear. Binds to chromatin. {ECO:0000250|UniProtKB:Q92560}. DISRUPTION PHENOTYPE: Neuronal hyperplasia, suggesting a role in Notch signaling pathway. {ECO:0000269|PubMed:20040115}. SIMILARITY: Belongs to the peptidase C12 family. BAP1 subfamily. {ECO:0000305}. SEQUENCE CAUTION: Sequence=AAI29507.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAK11034.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
UniProt ID: F1QJ12 |
CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707, ECO:0000256|RuleBase:RU361215}; SIMILARITY: Belongs to the peptidase C12 family. {ECO:0000256|RuleBase:RU361215}. |
UniProt ID: A0A8M2BLM6 |
CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707, ECO:0000256|RuleBase:RU361215}; SIMILARITY: Belongs to the peptidase C12 family. {ECO:0000256|RuleBase:RU361215}. |
UniProt ID: A0A8M2BL95 |
CATALYTIC ACTIVITY: Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707, ECO:0000256|RuleBase:RU361215}; SIMILARITY: Belongs to the peptidase C12 family. {ECO:0000256|RuleBase:RU361215}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |