UniProt ID: Q1L8Y6 |
FUNCTION: Required for primary cilia assembly. {ECO:0000269|Ref.2}. SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. Cytoplasm {ECO:0000250}. DISRUPTION PHENOTYPE: Embryos display defective melanosome transport and disruption of the ciliated Kupffer's vesicle phenotypes. BBIP1 morpholino knockdown results in bilateral cystic dilations of the pronephros. Pronephric cilia of morphants are abnormally short and fail to maintain a parallel orientation to the anteroposterior axis of the duct. Morphants also show increased frequency of situs inversus compared to wild-type and abnormal retinal development. {ECO:0000269|PubMed:24026985, ECO:0000269|Ref.2}. MISCELLANEOUS: BBIP10 interacts genetically with BBS1. SIMILARITY: Belongs to the BBIP10 family. {ECO:0000305}. |
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