UniProt ID: F1QZ15 |
FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Tprkb acts as an allosteric effector that regulates the t(6)A activity of the complex. {ECO:0000250|UniProtKB:Q9Y3C4}. SUBUNIT: Component of the EKC/KEOPS complex. {ECO:0000250|UniProtKB:Q9Y3C4}. SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y3C4}. Nucleus {ECO:0000250|UniProtKB:Q9Y3C4}. DISRUPTION PHENOTYPE: Embryos display primary microcephaly, leading to early lethality (PubMed:29346415, PubMed:28805828). Marked apoptosis is observed in the brain (telencephalon) (PubMed:28805828). Fishes do not show a renal phenotype, possibly as a result of early lethality (PubMed:28805828). {ECO:0000269|PubMed:28805828, ECO:0000269|PubMed:29346415}. SIMILARITY: Belongs to the CGI121/TPRKB family. {ECO:0000305}. |
UniProt ID: A0A8M9Q0F6 |
SIMILARITY: Belongs to the CGI121/TPRKB family. {ECO:0000256|ARBA:ARBA00005546, ECO:0000256|RuleBase:RU004398}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |