UniProt ID: F1RCR0 |
FUNCTION: Involved in pre-mRNA splicing. {ECO:0000256|RuleBase:RU367071}. SUBUNIT: Associated with the spliceosome. {ECO:0000256|RuleBase:RU367071}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367071}. SIMILARITY: Belongs to the SLU7 family. {ECO:0000256|ARBA:ARBA00007203, ECO:0000256|RuleBase:RU367071}. |
UniProt ID: Q5U3F2 |
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000250|UniProtKB:O95391}. SUBUNIT: Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I. {ECO:0000250|UniProtKB:O95391}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95391}. Nucleus speckle {ECO:0000250|UniProtKB:O95391}. Cytoplasm {ECO:0000250|UniProtKB:O95391}. Note=Predominantly nuclear. {ECO:0000250|UniProtKB:O95391}. SIMILARITY: Belongs to the SLU7 family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |