UniProt ID: E9QJ73 |
FUNCTION: Receptor for the C-X-C chemokines cxcl11.1 and cxcl11.6 (PubMed:25573892). Promotes macrophage chemotaxis to sites of bacterial infection (PubMed:20424185, PubMed:25573892). {ECO:0000269|PubMed:20424185, ECO:0000269|PubMed:25573892}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:25573892}; Multi-pass membrane protein {ECO:0000255}. DEVELOPMENTAL STAGE: Detected in developing macrophages at 28 hours post-fertilization (PubMed:20424185). Continues to be expressed in macrophages at 2 and 6 days post-fertilization (dpf) (PubMed:25573892). Also detected in neutrophils at 2 and 6 dpf (PubMed:25573892). {ECO:0000269|PubMed:20424185, ECO:0000269|PubMed:25573892}. DISRUPTION PHENOTYPE: Viable with no significant effect on survival (PubMed:25573892). Macrophage and neutrophil counts are normal (PubMed:25573892). Macrophage migration in response to cxcr3.2- independent stimuli is not affected, although the basal migration rate is reduced (PubMed:25573892). Macrophage migration to sites of bacterial infection by S.typhimurium or M.marinum is reduced (PubMed:20424185, PubMed:25573892). Dissemination of bacterial infection to distant sites and granuloma formation is also reduced (PubMed:25573892). {ECO:0000269|PubMed:20424185, ECO:0000269|PubMed:25573892}. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
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