UniProt ID: A0A8M9Q5V4 |
FUNCTION: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation. {ECO:0000256|PIRNR:PIRNR016408}. CATALYTIC ACTIVITY: Reaction=N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D- glucosamine 6-phosphate; Xref=Rhea:RHEA:23804, ChEBI:CHEBI:57513, ChEBI:CHEBI:57776; EC=5.4.2.3; Evidence={ECO:0000256|ARBA:ARBA00000558, ECO:0000256|PIRNR:PIRNR016408}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|PIRNR:PIRNR016408, ECO:0000256|PIRSR:PIRSR016408-3}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRNR:PIRNR016408, ECO:0000256|PIRSR:PIRSR016408-3}; PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2. {ECO:0000256|ARBA:ARBA00004865, ECO:0000256|PIRNR:PIRNR016408}. SIMILARITY: Belongs to the phosphohexose mutase family. {ECO:0000256|ARBA:ARBA00010231, ECO:0000256|PIRNR:PIRNR016408}. |
UniProt ID: Q5XFY0 |
FUNCTION: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation. {ECO:0000256|PIRNR:PIRNR016408}. CATALYTIC ACTIVITY: Reaction=N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D- glucosamine 6-phosphate; Xref=Rhea:RHEA:23804, ChEBI:CHEBI:57513, ChEBI:CHEBI:57776; EC=5.4.2.3; Evidence={ECO:0000256|ARBA:ARBA00000558, ECO:0000256|PIRNR:PIRNR016408}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|PIRNR:PIRNR016408, ECO:0000256|PIRSR:PIRSR016408-3}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRNR:PIRNR016408, ECO:0000256|PIRSR:PIRSR016408-3}; PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2. {ECO:0000256|ARBA:ARBA00004865, ECO:0000256|PIRNR:PIRNR016408}. SIMILARITY: Belongs to the phosphohexose mutase family. {ECO:0000256|ARBA:ARBA00010231, ECO:0000256|PIRNR:PIRNR016408}. |
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