UniProt ID: A9LMC0 |
FUNCTION: Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity). Plays an essential role in heart and skeletal muscle development. {ECO:0000250, ECO:0000269|PubMed:18765789}. SUBUNIT: Component of the BAF complex. Interacts with acetylated histones H3 and H4. Component of neuron-specific chromatin remodeling complex (nBAF complex), a subfamily of ATP-dependent SWI/SNF chromatin remodeling complexes (By similarity). {ECO:0000250|UniProtKB:P58269, ECO:0000250|UniProtKB:Q92784}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92784}. TISSUE SPECIFICITY: Expressed in the heart and somites. {ECO:0000269|PubMed:18765789}. DOMAIN: The PHD-type zinc fingers mediate the binding to acetylated histones. {ECO:0000250}. SEQUENCE CAUTION: Sequence=CAI11958.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
UniProt ID: A0A8M2B7M6 |
SIMILARITY: Belongs to the requiem/DPF family. {ECO:0000256|ARBA:ARBA00010539}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |