UniProt ID: F1QHM6 |
FUNCTION: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. {ECO:0000256|HAMAP- Rule:MF_03161}. CATALYTIC ACTIVITY: Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence={ECO:0000256|HAMAP-Rule:MF_03161}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-Rule:MF_03161}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-Rule:MF_03161}; SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000256|HAMAP- Rule:MF_03161}. SIMILARITY: Belongs to the sirtuin family. Class II subfamily. {ECO:0000256|HAMAP-Rule:MF_03161}. |
UniProt ID: Q5XJ86 |
FUNCTION: NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. {ECO:0000256|HAMAP- Rule:MF_03161}. CATALYTIC ACTIVITY: Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence={ECO:0000256|HAMAP-Rule:MF_03161}; COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-Rule:MF_03161}; Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-Rule:MF_03161}; SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000256|HAMAP- Rule:MF_03161}. SIMILARITY: Belongs to the sirtuin family. Class II subfamily. {ECO:0000256|HAMAP-Rule:MF_03161}. |
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