UniProt ID: Q5XJJ3 |
FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. {ECO:0000256|ARBA:ARBA00003411, ECO:0000256|RuleBase:RU368017}. SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c. {ECO:0000256|RuleBase:RU368017}. SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|RuleBase:RU368017}. Mitochondrion inner membrane {ECO:0000256|RuleBase:RU368017}. SIMILARITY: Belongs to the eukaryotic ATPase B chain family. {ECO:0000256|ARBA:ARBA00007479, ECO:0000256|RuleBase:RU368017}. |
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