UniProt ID: A0A8M2B834 |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. |
UniProt ID: Q5XJA5 |
FUNCTION: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36653451). Acts via its association with eef2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (PubMed:36653451). Plays a key role in ribosome hibernation in the mature egg by promoting ribosome stabilization (PubMed:36653451). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo (PubMed:36653451). {ECO:0000269|PubMed:36653451}. SUBUNIT: Associates with ribosomes; promoting ribosome stabilization (PubMed:36653451). Interacts with eef2/eEF2; promoting ribosome stabilization (PubMed:36653451). {ECO:0000269|PubMed:36653451}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5JVS0}. Cytoplasm {ECO:0000250|UniProtKB:Q9I9R0}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus speckle {ECO:0000250|UniProtKB:Q5JVS0}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q5JVS0}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q9I9R0}. SIMILARITY: Belongs to the SERBP1-HABP4 family. {ECO:0000305}. |
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