UniProt ID: A4QP16 |
FUNCTION: May be involved in transcriptional regulation (PubMed:23071114). Required for progression through late erythroid differentiation (PubMed:23071114). May be involved in vasculogenesis (PubMed:23071114). {ECO:0000269|PubMed:23071114}. SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. DEVELOPMENTAL STAGE: Expressed from the 1-cell stage, before the onset of zygotic expression, then, during gastrulation, at 6 hours post- fertilization (hpf), expression is absent, and at 11-12 hpf, coincident with segmentation, expression returns until 72 hpf. {ECO:0000269|PubMed:23071114}. DISRUPTION PHENOTYPE: Morpholino knockdown has no effect on overall morphology, and at the onset of blood circulation at 24 hours post- fertilization (hpf), blood cells are present, however between 33 and 48 hpf, blood cells are absent, and embryos develop cardiac edema (PubMed:23071114). Hemoglobin undetectable (PubMed:23071114). Some embryos recovered blood circulation at day 4 after knockdown, whereas others became severely edematous at day 4-5 and died by about 7 days (PubMed:23071114). At 28 and 48 hpf, expression of band3 almost abolished; embryonic alpha-globin1 also significantly reduced at 28 hpf (PubMed:23071114). {ECO:0000269|PubMed:23071114}. |
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