UniProt ID: Q1LWZ0 |
FUNCTION: Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Seems to regulate the assembly of both ODAs and their axonemal docking complex onto ciliary microtubules (By similarity). Regulates ciliary and flagellar motility and is required for cilia- driven determination of body laterality (PubMed:31240264). {ECO:0000250|UniProtKB:Q32L26, ECO:0000269|PubMed:31240264}. FUNCTION: Regulates ciliary motility and is required for cilia-driven determination of body laterality. {ECO:0000269|PubMed:31240264}. SUBUNIT: Component of the outer dynein arm-docking complex along with ODAD1, ODAD2, ODAD3 and ODAD4. {ECO:0000250|UniProtKB:Q32L26}. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q96M63}. DISRUPTION PHENOTYPE: Knockout mutants show situs invertus but normal formation of Kupffer's vesicle (KV) cilia (PubMed:31240264). However, many of the KV cilia in the mutant beat with an irregular cycle in contrast to the smooth rotary movement in wild-type fish (PubMed:31240264). {ECO:0000269|PubMed:31240264}. SEQUENCE CAUTION: Sequence=AAI71473.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI71475.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; |
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