UniProt ID: Q6AZV8 |
FUNCTION: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. {ECO:0000256|ARBA:ARBA00033727}. CATALYTIC ACTIVITY: Reaction=3-(4-hydroxyphenyl)pyruvate + O2 = CO2 + homogentisate; Xref=Rhea:RHEA:16189, ChEBI:CHEBI:15379, ChEBI:CHEBI:16169, ChEBI:CHEBI:16526, ChEBI:CHEBI:36242; EC=1.13.11.27; Evidence={ECO:0000256|ARBA:ARBA00033692}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16190; Evidence={ECO:0000256|ARBA:ARBA00033692}; COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000256|PIRSR:PIRSR009283-1}; Note=Binds 1 Fe cation per subunit. {ECO:0000256|PIRSR:PIRSR009283-1}; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004406}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004395}. SIMILARITY: Belongs to the 4HPPD family. {ECO:0000256|ARBA:ARBA00005877, ECO:0000256|PIRNR:PIRNR009283}. |
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