UniProt ID: Q6DEL1 |
FUNCTION: Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen. {ECO:0000250|UniProtKB:Q9NVC3}. CATALYTIC ACTIVITY: Reaction=L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out); Xref=Rhea:RHEA:71383, ChEBI:CHEBI:29101, ChEBI:CHEBI:58048; Evidence={ECO:0000250|UniProtKB:Q9NVC3}; CATALYTIC ACTIVITY: Reaction=L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out); Xref=Rhea:RHEA:68236, ChEBI:CHEBI:29101, ChEBI:CHEBI:58359; Evidence={ECO:0000250|UniProtKB:Q9NVC3}; SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9NVC3}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BWH0}. Note=In neurons, located in soma. {ECO:0000250|UniProtKB:Q8BWH0}. SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family. {ECO:0000305}. |
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