UniProt ID: Q5PQZ3 |
FUNCTION: Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health (By similarity). In nucleus, may function as a secondary coactivator for nuclear receptors (By similarity). {ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000250|UniProtKB:Q6PML9}. CATALYTIC ACTIVITY: Reaction=2 H(+)(out) + Zn(2+)(in) = 2 H(+)(in) + Zn(2+)(out); Xref=Rhea:RHEA:72627, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105; Evidence={ECO:0000250|UniProtKB:Q6PML9}; SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q6PML9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6PML9}. Nucleus {ECO:0000250|UniProtKB:Q6PML9}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6PML9}. Note=Partial co- localization with endoplasmic reticulum. Linked to mitochondrial ribosomes. {ECO:0000250|UniProtKB:Q6PML9}. SIMILARITY: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}. SEQUENCE CAUTION: Sequence=CAE30408.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
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