UniProt ID: Q5TZ07 |
FUNCTION: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine- 1-phosphate. {ECO:0000250|UniProtKB:Q8IY26}. CATALYTIC ACTIVITY: Reaction=H2O + presqualene diphosphate = H(+) + phosphate + presqualene monophosphate; Xref=Rhea:RHEA:67968, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57310, ChEBI:CHEBI:176803; Evidence={ECO:0000250|UniProtKB:Q8IY26}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67969; Evidence={ECO:0000250|UniProtKB:Q8IY26}; CATALYTIC ACTIVITY: Reaction=H2O + presqualene monophosphate = phosphate + presqualene alcohol; Xref=Rhea:RHEA:68024, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:176803, ChEBI:CHEBI:176962; Evidence={ECO:0000250|UniProtKB:Q8IY26}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68025; Evidence={ECO:0000250|UniProtKB:Q8IY26}; CATALYTIC ACTIVITY: Reaction=(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:48128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:88226, ChEBI:CHEBI:175763; Evidence={ECO:0000250|UniProtKB:Q8IY26}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48129; Evidence={ECO:0000250|UniProtKB:Q8IY26}; CATALYTIC ACTIVITY: Reaction=(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate; Xref=Rhea:RHEA:48132, ChEBI:CHEBI:15377, ChEBI:CHEBI:16619, ChEBI:CHEBI:43474, ChEBI:CHEBI:88226; Evidence={ECO:0000250|UniProtKB:Q8IY26}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48133; Evidence={ECO:0000250|UniProtKB:Q8IY26}; CATALYTIC ACTIVITY: Reaction=(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)- geranylgeranyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:68008, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58756, ChEBI:CHEBI:144936; Evidence={ECO:0000250|UniProtKB:Q8IY26}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68009; Evidence={ECO:0000250|UniProtKB:Q8IY26}; CATALYTIC ACTIVITY: Reaction=(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)- geranylgeraniol + phosphate; Xref=Rhea:RHEA:68016, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46762, ChEBI:CHEBI:144936; Evidence={ECO:0000250|UniProtKB:Q8IY26}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68017; Evidence={ECO:0000250|UniProtKB:Q8IY26}; CATALYTIC ACTIVITY: Reaction=(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + H(+) + phosphate; Xref=Rhea:RHEA:47944, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58057, ChEBI:CHEBI:88107; EC=3.6.1.68; Evidence={ECO:0000250|UniProtKB:Q8IY26}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:47945; Evidence={ECO:0000250|UniProtKB:Q8IY26}; CATALYTIC ACTIVITY: Reaction=(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate; Xref=Rhea:RHEA:68020, ChEBI:CHEBI:15377, ChEBI:CHEBI:17447, ChEBI:CHEBI:43474, ChEBI:CHEBI:88107; Evidence={ECO:0000250|UniProtKB:Q8IY26}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:68021; Evidence={ECO:0000250|UniProtKB:Q8IY26}; CATALYTIC ACTIVITY: Reaction=1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2- dihexadecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:43236, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929; Evidence={ECO:0000250|UniProtKB:Q8IY26}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43237; Evidence={ECO:0000250|UniProtKB:Q8IY26}; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IY26}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY26}. Nucleus envelope {ECO:0000250|UniProtKB:Q8IY26}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q8IY26}. SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}. |
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