FUNCTION: Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (PubMed:25848753). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). {ECO:0000250|UniProtKB:Q8BHY8, ECO:0000250|UniProtKB:Q9Y5W7, ECO:0000269|PubMed:25848753}. SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9Y5W7}; Multi-pass membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000250|UniProtKB:Q9Y5W7}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHY8}. DISRUPTION PHENOTYPE: Loss of neural tissue volume: neuronal cell death is associated with impaired autophagic degradation. {ECO:0000269|PubMed:25848753}. SIMILARITY: Belongs to the sorting nexin family. {ECO:0000305}. |