UniProt ID: Q5RH51 |
FUNCTION: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases (By similarity). {ECO:0000250|UniProtKB:O75063}. CATALYTIC ACTIVITY: Reaction=3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D- xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)- beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:19461, Rhea:RHEA-COMP:12571, Rhea:RHEA- COMP:14558, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:132090, ChEBI:CHEBI:140494, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:O75063}; COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:Q9XTW2}; SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:O75063}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O75063}. SIMILARITY: Belongs to the FAM20 family. {ECO:0000305}. |
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