UniProt ID: Q6DHK5 |
FUNCTION: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). {ECO:0000256|RuleBase:RU368071}. CATALYTIC ACTIVITY: Reaction=2 glutathione + H(+) + methylarsonate = glutathione disulfide + H2O + methylarsonous acid; Xref=Rhea:RHEA:15969, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17826, ChEBI:CHEBI:33409, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297; EC=1.20.4.2; Evidence={ECO:0000256|ARBA:ARBA00001437, ECO:0000256|RuleBase:RU368071}; CATALYTIC ACTIVITY: Reaction=2 glutathione + L-dehydroascorbate = glutathione disulfide + L-ascorbate; Xref=Rhea:RHEA:24424, ChEBI:CHEBI:38290, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:58539; EC=1.8.5.1; Evidence={ECO:0000256|ARBA:ARBA00000509, ECO:0000256|RuleBase:RU368071}; CATALYTIC ACTIVITY: Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000256|ARBA:ARBA00000710, ECO:0000256|RuleBase:RU368071}; SIMILARITY: Belongs to the GST superfamily. Omega family. {ECO:0000256|ARBA:ARBA00011067, ECO:0000256|RuleBase:RU368071}. |
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