UniProt ID: Q6DHQ1 |
FUNCTION: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity). {ECO:0000250}. SUBUNIT: Homodimer. {ECO:0000250}. SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain (By similarity). {ECO:0000250}. DOMAIN: The C-terminal coiled coil region mediates homodimerization. It is essential for normal subcellular localization (By similarity). {ECO:0000250}. SIMILARITY: Belongs to the hydrogen channel family. {ECO:0000305}. |
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