UniProt ID: Q6DHE8 |
FUNCTION: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. {ECO:0000250|UniProtKB:P61586}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:26190758}; Lipid-anchor {ECO:0000250|UniProtKB:P61586}; Cytoplasmic side {ECO:0000250|UniProtKB:P61586}. PTM: (Microbial infection) Glycosylated at Tyr-34 by Yersinia ruckeri toxin Afp18. Mono-O-GlcNAcylation by Afp18 inhibits RhoA activation by guanine nucleotide exchange factors and blocks RhoA signaling. {ECO:0000305|PubMed:26190758}. SIMILARITY: Belongs to the small GTPase superfamily. Rho family. {ECO:0000305}. |
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