UniProt ID: Q6GQM0 |
FUNCTION: Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the microtubule organising center (MTOC) at the center of the cell. Probably binds cholesterol and requires the presence of cholesterol in membranes to function in microtubule-mediated retrograde organelle transport. Binds phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3,5-bisphosphate. {ECO:0000250|UniProtKB:Q6NVG5}. SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q6NVG5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NVG5}. Melanosome membrane {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor {ECO:0000250|UniProtKB:Q6NVG5}. Lysosome membrane {ECO:0000250|UniProtKB:Q6NVG5}; Lipid-anchor {ECO:0000250|UniProtKB:Q6NVG5}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6NVG5}. SIMILARITY: Belongs to the melanoregulin family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |