UniProt ID: Q6IQT4
FUNCTION: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. {ECO:0000250|UniProtKB:P61201}.
SUBUNIT: Component of the CSN complex, probably composed of cops1, cops2, cops3, cops4, cops5, cops6, cops7, cops8 and cops9. {ECO:0000250|UniProtKB:P61201}.
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61201}. Nucleus {ECO:0000250|UniProtKB:P61201}.
SIMILARITY: Belongs to the CSN2 family. {ECO:0000305}.
This information was provided by UniProt through a collaboration with ZFIN. (1)