UniProt ID: Q6IQD6 |
FUNCTION: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation. {ECO:0000256|HAMAP- Rule:MF_03173}. CATALYTIC ACTIVITY: Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3; Evidence={ECO:0000256|ARBA:ARBA00000582, ECO:0000256|HAMAP- Rule:MF_03173}; SUBUNIT: Monomer and homodimer. Interacts with COIL (via C-terminus). {ECO:0000256|HAMAP-Rule:MF_03173}. SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000256|HAMAP- Rule:MF_03173}. Nucleus, Cajal body {ECO:0000256|HAMAP-Rule:MF_03173}. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells. {ECO:0000256|HAMAP-Rule:MF_03173}. SIMILARITY: Belongs to the adenylate kinase family. AK6 subfamily. {ECO:0000256|HAMAP-Rule:MF_03173}. CAUTION: Lacks conserved residue(s) required for the propagation of feature annotation. {ECO:0000256|HAMAP-Rule:MF_03173}. |
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