UniProt ID: Q708S3 |
FUNCTION: Probable cation channel with high affinity for sodium. {ECO:0000269|PubMed:14970195}. SUBUNIT: Homotrimer or heterotrimer with other ASIC proteins. {ECO:0000250}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. TISSUE SPECIFICITY: Expressed in central nervous system. {ECO:0000269|PubMed:14970195}. DEVELOPMENTAL STAGE: Expressed along the tract of the anterior commissure between 24 and 30 hours post-fertilization (hpf). At 30 hpf, expressed in cells along the tract of the postoptic commissure. Expressed in preoptic area from 48 hpf until 96 hpf. Expressed in posterior hypothalamus, ventral midbrain, hindbrain and retinal ganglion cells by 48 hpf. These domains of expression persisted and strengthened in older embryos. MISCELLANEOUS: In vitro, has no proton-gated channel activity. SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. {ECO:0000305}. |
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