UniProt ID: Q708S4 |
FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. {ECO:0000269|PubMed:14970195}. SUBUNIT: Homotrimer or heterotrimer with other ASIC proteins. {ECO:0000250}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. TISSUE SPECIFICITY: Expressed in central nervous system. {ECO:0000269|PubMed:14970195}. DEVELOPMENTAL STAGE: First expressed at 48 hours post-fertilization (hpf). Expressed in dorsal midbrain and in retinal ganglion cells. {ECO:0000269|PubMed:14970195}. SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily. {ECO:0000305}. |
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