UniProt ID: Q708S7 |
FUNCTION: Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. {ECO:0000269|PubMed:14970195}. ACTIVITY REGULATION: Inhibited by the diuretic amiloride. {ECO:0000269|PubMed:14970195}. SUBUNIT: Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with asic1/accn2c. {ECO:0000250, ECO:0000269|PubMed:14970195}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14970195}; Multi-pass membrane protein {ECO:0000269|PubMed:14970195}. TISSUE SPECIFICITY: Expressed in central nervous system. Faintly expressed in the trunk, presumably in dorsal root ganglia. {ECO:0000269|PubMed:14970195}. DEVELOPMENTAL STAGE: First detected 48 hours post-fertilization (hpf) in the ventral thalamus, ventral midbrain, ventral cerebellum, ventral hindbrain, dorsal thalamus, hypothalamus, telencephalon, along the tract of the anterior commissure. Weakly expressed in the dorsal midbrain and olfactory bulb. Expression increases by 96 hpf and is detected in the tectum and trunk. {ECO:0000269|PubMed:14970195}. DOMAIN: Channel opening involves a conformation change that affects primarily the extracellular domain and the second transmembrane helix and its orientation in the membrane. In the open state, the second transmembrane helix is nearly perpendicular to the plane of the membrane; in the desensitized state it is strongly tilted. Besides, the second transmembrane domain is discontinuously helical in the open state. The GAS motif of the selectivity filter is in an extended conformation, giving rise to a distinct kink in the polypeptide chain. A domain swap between subunits gives rise to a full-length transmembrane helix (By similarity). {ECO:0000250}. SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily. {ECO:0000305}. |
UniProt ID: A0A8M9QIQ3 |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. |
UniProt ID: B0R1B0 |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |