UniProt ID: Q7ZV26 |
FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) (By similarity). {ECO:0000250}. SUBUNIT: Belongs to the multiprotein complex Integrator. Component of the SOSS complex, composed of soss-b (soss-b1/nabp2 or soss-b2/nabp1), soss-a/ints3 and soss-c/inip (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear foci following DNA damage. {ECO:0000250}. SIMILARITY: Belongs to the SOSS-C family. {ECO:0000305}. |
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