UniProt ID: B2GPA1 |
FUNCTION: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A- mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000256|ARBA:ARBA00024977}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the RMI1 family. {ECO:0000256|ARBA:ARBA00006395}. |
UniProt ID: A0A8M9QDM9 |
FUNCTION: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A- mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. {ECO:0000256|ARBA:ARBA00024977}. SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the RMI1 family. {ECO:0000256|ARBA:ARBA00006395}. |
UniProt ID: Q7ZVM9 |
FUNCTION: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A- mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). {ECO:0000250}. SUBUNIT: Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. {ECO:0000250}. SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. SIMILARITY: Belongs to the RMI1 family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |