UniProt ID: Q7ZVU7 |
FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000256|ARBA:ARBA00002587}. CATALYTIC ACTIVITY: Reaction=H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3- (methylsulfanyl)propylamine; Xref=Rhea:RHEA:15981, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57443, ChEBI:CHEBI:59789; EC=4.1.1.50; Evidence={ECO:0000256|PIRNR:PIRNR001355}; COFACTOR: Name=pyruvate; Xref=ChEBI:CHEBI:15361; Evidence={ECO:0000256|PIRNR:PIRNR001355}; Note=Binds 1 pyruvoyl group covalently per subunit. {ECO:0000256|PIRNR:PIRNR001355}; PATHWAY: Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1. {ECO:0000256|ARBA:ARBA00004911, ECO:0000256|PIRNR:PIRNR001355}. SIMILARITY: Belongs to the eukaryotic AdoMetDC family. {ECO:0000256|ARBA:ARBA00008466, ECO:0000256|PIRNR:PIRNR001355}. |
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