UniProt ID: Q7ZUN8 |
FUNCTION: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. {ECO:0000250|UniProtKB:O15498}. SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Probably cycles through vesicles between Golgi and endosomes. {ECO:0000250}. DOMAIN: The longin domain regulates palmitoylation and membrane targeting. {ECO:0000250}. PTM: Palmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting. {ECO:0000250|UniProtKB:O15498}. PTM: Farnesylation is required for Golgi targeting. {ECO:0000250|UniProtKB:O15498}. SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}. |
UniProt ID: B2GTI5 |
FUNCTION: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. {ECO:0000256|ARBA:ARBA00025256}. SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00025701}; Lipid-anchor {ECO:0000256|ARBA:ARBA00025701}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00025701}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004444}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004444}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004444}. Membrane {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004423}. SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000256|ARBA:ARBA00008025}. |
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