UniProt ID: Q803X4 |
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. {ECO:0000250|UniProtKB:Q9NV06}. FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex. {ECO:0000250|UniProtKB:Q9NV06}. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Component of the DCX(DCAF13) E3 ubiquitin ligase complex, at least composed of CUL4 (CUL4A or CUL4B), DDB1, DCAF13 and RBX1. {ECO:0000250|UniProtKB:Q9NV06}. SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NV06}. Note=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component. {ECO:0000250|UniProtKB:Q9NV06}. SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family. {ECO:0000305}. |
UniProt ID: B2GQH5 |
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000256|ARBA:ARBA00004906}. SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. SIMILARITY: Belongs to the WD repeat DCAF13/WDSOF1 family. {ECO:0000256|ARBA:ARBA00005649}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |