UniProt ID: Q7ZVT3
FUNCTION: Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:21273447). Required for centrosome biogenesis and duplication: required both for mother-centriole- dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity). {ECO:0000250|UniProtKB:Q6UVJ0, ECO:0000269|PubMed:21273447}.
SUBUNIT: Nine homodimers form a cartwheel structure with an internal diameter of 23 nM and radial spokes connecting to the microtubule triplets. {ECO:0000269|PubMed:21273447}.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21273447}. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. {ECO:0000250|UniProtKB:Q6NRG6}.
DOMAIN: The 35 nM long coiled-coil domain mediates homodimerization while the globular N-terminus links the dimers at an angle of 40 degrees to form the inner ring. {ECO:0000269|PubMed:21273447}.
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