UniProt ID: Q7SYK7 |
FUNCTION: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. {ECO:0000250|UniProtKB:P00505}. CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate; Xref=Rhea:RHEA:21824, ChEBI:CHEBI:16452, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991; EC=2.6.1.1; Evidence={ECO:0000250|UniProtKB:P00505}; CATALYTIC ACTIVITY: Reaction=2-oxoglutarate + L-kynurenine = H2O + kynurenate + L- glutamate; Xref=Rhea:RHEA:65560, ChEBI:CHEBI:15377, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959, ChEBI:CHEBI:58454; EC=2.6.1.7; Evidence={ECO:0000250|UniProtKB:P00505}; COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250|UniProtKB:P00505}; SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P00505}. SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P00505}. Cell membrane {ECO:0000250|UniProtKB:P00505}. DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results in brain developmental defects. Morphants show a small head and seizure- like electroencephalography spikes. Additional defects include slow circulation, bend body and pericardial edema. {ECO:0000269|PubMed:31422819}. MISCELLANEOUS: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}. |
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