UniProt ID: Q6NYM1 |
FUNCTION: Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity). {ECO:0000250}. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of cul3, klhl21 and rbx1. {ECO:0000250}. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to the spindle midzone and targets CUL3 to this region. {ECO:0000250}. |
UniProt ID: A0A8M9P526 |
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000256|ARBA:ARBA00004906}. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |