UniProt ID: Q6NYG8 |
FUNCTION: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. {ECO:0000250|UniProtKB:Q12882}. CATALYTIC ACTIVITY: Reaction=5,6-dihydrouracil + NADP(+) = H(+) + NADPH + uracil; Xref=Rhea:RHEA:18093, ChEBI:CHEBI:15378, ChEBI:CHEBI:15901, ChEBI:CHEBI:17568, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.2; Evidence={ECO:0000250|UniProtKB:Q12882}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:18095; Evidence={ECO:0000250|UniProtKB:Q12882}; CATALYTIC ACTIVITY: Reaction=5,6-dihydrothymine + NADP(+) = H(+) + NADPH + thymine; Xref=Rhea:RHEA:58284, ChEBI:CHEBI:15378, ChEBI:CHEBI:17821, ChEBI:CHEBI:27468, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.2; Evidence={ECO:0000250|UniProtKB:Q12882}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:58286; Evidence={ECO:0000250|UniProtKB:Q12882}; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250|UniProtKB:Q28943}; Note=Binds 2 FAD. {ECO:0000250|UniProtKB:Q28943}; COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250|UniProtKB:Q28943}; Note=Binds 2 FMN. {ECO:0000250|UniProtKB:Q28943}; COFACTOR: Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250|UniProtKB:Q28943}; Note=Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit. {ECO:0000250|UniProtKB:Q28943}; PATHWAY: Amino-acid biosynthesis; beta-alanine biosynthesis. {ECO:0000250|UniProtKB:Q12882}. SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q12882}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q12882}. SIMILARITY: Belongs to the dihydropyrimidine dehydrogenase family. {ECO:0000305}. |
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