UniProt ID: Q6NYV9 |
FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. {ECO:0000250, ECO:0000269|PubMed:20178782}. SUBUNIT: Component of the PAF1 complex, which at least consists of cdc73, paf1, leo1, ctr9 and rtf1 (By similarity). The PAF1 complex interacts with PHF5A (By similarity). Interacts with ctr9 (PubMed:21338598). {ECO:0000250|UniProtKB:Q5XJE5, ECO:0000250|UniProtKB:Q8WVC0, ECO:0000269|PubMed:21338598}. SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20178782}. SIMILARITY: Belongs to the LEO1 family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |