UniProt ID: Q6NYK3 |
FUNCTION: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. {ECO:0000250|UniProtKB:Q7Z698}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q924S7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q924S7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q924S7}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q7Z698}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q7Z698}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7Z698}. Cytoplasm {ECO:0000250|UniProtKB:Q7Z698}. DISRUPTION PHENOTYPE: Morpholino knockdown is associated with increased Erk phosphorylation levels and results in a high incidence of embryos showing delayed gastrulation, or delay in elongation during the segmentation stage, with reduced formation of the head and tailbud. Morphants show yolk elongation at 12 hours post-fertilization, indicating enhanced MAPK signaling. {ECO:0000269|PubMed:34626534}. |
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