UniProt ID: Q7SZR5 |
FUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. {ECO:0000250|UniProtKB:P63165}. SUBUNIT: Interacts with sae2, ube2i, ranbp2, pias1 and pias2 (By similarity). Covalently attached to a number of proteins (By similarity). {ECO:0000250|UniProtKB:P63165}. SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:P63165}. Nucleus speckle {ECO:0000250|UniProtKB:P63166}. Cytoplasm {ECO:0000250|UniProtKB:P63165}. Nucleus, PML body {ECO:0000250|UniProtKB:P63165}. Cell membrane {ECO:0000250|UniProtKB:P63165}. Nucleus {ECO:0000250|UniProtKB:P63165}. PTM: Cleavage of precursor form by a sentrin-specific protease is necessary for function. {ECO:0000250|UniProtKB:P63165}. SIMILARITY: Belongs to the ubiquitin family. SUMO subfamily. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |